L-(+)-Amethopterin hydrate (Methotrexate)
CAS: 59-05-2
Molecular Formula: C20H22N8O5
Molecular Weight: 454.44
Product Detail
| Product Code | 30186373 | ||||
| Product Name | L-(+)-Amethopterin hydrate (Methotrexate) | ||||
| Categories | Bioactive Small Molecules Research Organics & Inorganics | ||||
| CAS | 59-05-2 | ||||
| Molecular Formula | C20H22N8O5 | ||||
| Molecular Weight | 454.44 | ||||
| Storage Details | -15 to -20 °C | ||||
| Harmonised Tariff Code | 2933599590 |
Product Specification
| Grade | Ph. Eur. 8.3 | ||||
| Water | <13% | ||||
| Impurity B | NMT 0.3% | ||||
| Heavy metals | NMT 20ppm | ||||
| Bacterial endotoxin | NMT 0.1 EU/mg | ||||
| Acetone | NMT 1000 ppm | ||||
| Impurity C | NMT 0.5% | ||||
| Solubility | Practically insolubile in water, in ethanol (96%) and in methylene chloride. It dissolves in dilute mineral acids and in dilute solutions od alkali hydroxides and carbonates | ||||
| Assay | 98 – 102% | ||||
| Sulphated Ash | NMT 0.1% | ||||
| Ethanol | NMT 2000 ppm | ||||
| Appearance | Yellow or orange crystalline, hygroscopic powder | ||||
| Enantiomeric Purity | NMT3.0% | ||||
| Identification (IR) | The IR spectrum of sample exhibits maxima only at the same wavelength as that a similar preparation of methotrexate CRS | ||||
| Impurity E | NMT 0.3% | ||||
| Impurity H | NMT 0.2% | ||||
| Impurity I | NMT 0.2% | ||||
| Ethyl Ether | NMT 500 ppm |
Safety Information
| Pictograms |
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| Signal word | Danger | ||||
| Hazard statements | H301: Toxic if swallowed
H315: Causes skin irritation H319: Causes serious eye irritation H360: May damage fertility or the unborn child |
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| Precautionary statements | P201: Obtain special instructions before use
P280: Wear protective gloves/protective clothing/eye protection/face protection P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do, continue rinsing P308+313: IF exposed or concerned: Get medical advice/attention |